tailieunhanh - GUIDELINE FOR THE DIAGNOSIS AND MANAGEMENT OF COELIAC DISEASE IN CHILDREN

A full-fledged study will begin in 2010, aiming to follow approximately 60,000 children throughout Japan until age 12. First, some ten Unit Centers will be selected throughout Japan. They will be comprised of social medicine, obstetrics and gynecology, and pediatric departments at universities and research institutes. With cooperation from regional medical organizations, these Unit Centers will be responsible for enrolling pregnant women, collecting biological samples, and other operations that require contact with the target population. In addition, a Core Center will be established at the National Institute for Environmental Studies. The center will be responsible for planning and coordinating the. | Guideline for the diagnosis and management of Coeliac disease in children Coeliac Working Group of BSPGHAN This guideline is based on the NASPGHAN Celiac Guideline of 2005 See References by kind permission and the original guideline from the Welsh Gastroenterology MCN to whom we are grateful for allowing us to use their template document. The 2006 BSG Coeliac Guideline for Adult Coeliac Disease will be available soon on the BSG website Coeliac Disease CD is a reversible immune-mediated enteropathy caused by a permanent sensitivity to gluten in wheat and related proteins in barley and rye in genetically susceptible individuals . 1. WHO TO TEST The prevalence of coeliac disease is estimated to be 1 100 in the UK. Universal population screening is not currently advised. However there should be low threshold for investigating both symptomatic children and those with associated conditions. A. Symptomatic children GI Tract and non-GI Tract symptoms Persistent diarrhoea Faltering growth idiopathic short stature Abdominal pain vomiting constipation abdominal distension Dermatitis herpetiformis Dental enamel defects Osteoporosis pathological fractures Delayed menarche Unexplained anaemia or Iron deficient anaemia unresponsive to treatment Recurrent aphthous stomatitis Unexplained raised transaminases Lassitude weakness Irritable bowel syndrome Also consider JCA epilepsy with associated intracranial calcification unexplained neurological problems palsies neuropathies migraine B. Asymptomatic but with associated condition estimated lifetime prevalence Type I diabetes 8 Selective IgA deficiency - Down s 5-12 Williams and Turner s - Syndrome Autoimmune thyroiditis 15 Relatives of coeliac patient o 1st degree relative 10 o HLA matched sibling 30 - 40 o Monozygotic twin 70 If screening parents patients families should be counselled pre-testing as to relative risks of untreated coeliac disease and need for biopsy and GFD should .

• Sức khỏe trẻ em
• General Epidemics
• Mathematical Approach
• Biomedical Importance
• Host Genetic Factors
• Infectious Diseases
• Emerging Diseases
• Portuguese School (Adolescent)
• College Students
• Knowledge
• Methods of screening