tailieunhanh - Prevalence of Celiac Disease among Children in Finland

Historically, genetic and genomic techniques in paediatrics have been most intensively applied to the study of single gene disorders. New technologies in genomics are providing us with the ability to obtain vast amounts of data which is revolutionizing the potential for unravelling the complexity of multi-gene as well as complex diseases, with direct and significant impacts on child and adult health across Canada. Differences in Physiology Child health genomics must be regarded as a distinct form of health genomics, as the physiology of children is inherently different than that of adults. Attempting to treat childhood diseases with therapies designed for. | The new ENGLAND journal of medicine original article Prevalence of Celiac Disease among Children in Finland Markku Maki . . Kirsi Mustalahti . Jorma Kokkonen . . Petri Kulmala . . Mila Haapalahti . Tuomo Karttunen . Jorma Ilonen . . Kaija Laurila . Ingrid Dahlbom . Tony Hansson . Peter Hopfl . and Mikael Knip . . ABSTRACT background Wheat rye and barley proteins induce celiac disease an autoimmune type ofgastroin-testinal disorder in genetically susceptible persons. Because the disease may be underdiagnosed we estimated the prevalence of the disease and tested the hypothesis that assays for serum autoantibodies can be used to detect untreated celiac disease and that positive findings correlate with specific HLA haplotypes. methods Serum samples were collected from 3654 students age range 7 to 16 years in 1994 and screened in 2001 for endomysial and tissue transglutaminase antibodies. HLA typing was also performed on stored blood samples. All antibody-positive subjects were asked to undergo small-bowel biopsy in 2001. results Of the 3654 subjects 56 percent had positive antibody tests as determined in 2001. Results ofthe two antibody tests were highly concordant. As of1994 none ofthe subjects had received a clinical diagnosis ofceliac disease but 10 who had positive tests for both antibodies in serum obtained in 1994 received the diagnosis between 1994 and 2001. Of the 36 other subjects with positive antibody assays who agreed to undergo biopsy in 2001 27 had evidence of celiac disease on biopsy. Thus the estimated biopsy-proved prevalence was 1 case in 99 children. All but two ofthe antibody-positive subjects had either the HLA-DQ2 or the HLA-DQ8 haplotype. The prevalence ofthe combination of antibody positivity and an HLA haplotype associated with celiac disease was 1 in 67. From the Pediatric Research Center Medical School University of Tampere Tampere Finland . . . the Department of .

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