tailieunhanh - báo cáo khoa học: " Bridging the gap between epigenetics research and nutritional public health interventions"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Bridging the gap between epigenetics research and nutritional public health interventions | Burdge and Lillycrop Genome Medicine 2010 2 80 http content 2 11 80 w Genome Medicine COMMENTARY L__ Bridging the gap between epigenetics research and nutritional public health interventions Graham C Burdge1 and Karen A Lillycrop2 Abstract Epigenetic processes primarily DNA methylation and covalent modifications of histones regulate the transcriptional activity of genes in a manner that can be modified by environmental cues. This allows variation in the expression of the transcriptome without changes in the genome. Constraint in the early life environment such as poor early nutrition is associated with increased risk of non-communicable diseases including cardio-metabolic disease and cancer in later life. Such induced phenotypic change involves environmental signals acting through developmental plasticity. Recent studies in humans and in animal models show that epigenetic processes in particular DNA methylation have a central role in the induction and stability of novel phenotypes and in increased disease risk. Identification of such processes suggests the potential for developing biomarkers of disease risk and for interventions to prevent or reverse the adverse effects of a poor early life environment. At present knowledge in this area is limited to proof-of-principle studies in animal models and some initial studies in humans. Before such findings can be translated into reliable biomarkers and safe effective interventions several fundamental questions need to be answered. In order to achieve this new technologies will be needed to support large cohort studies. Despite the early stage of knowledge in this field and the intellectual technological and financial challenges epigenetic research has substantial potential for public health benefits. Correspondence institute of Human Nutrition University of Southampton School of Medicine Institute of Developmental Sciences Building MP887 Southampton General Hospital

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