tailieunhanh - Core Topics in Operating Department Practice Anaesthesia and Critical Care – Part 8

Sau đó, một giai đoạn của thời gian nghỉ ngơi theo cùng với việc giảm việc sử dụng của tiêm IV. Nói chung là giả định rằng không có nghiên cứu sâu hơn liên quan đến IV liên quan đến gây mê cho đến năm 1872, khi Pierre-Cyprien quặng được sử dụng IV chloral hydrate như thuốc gây mê duy nhất đã được trao cho tổng cộng 36 bệnh nhân phẫu thuật | 146 K. Henshaw that the dogs displayed a mild inebriation noted after injection. In 1664 a German scientist named Daniel Meyer noted that when needles were inserted into the tongues of dogs following the injection of IV opium the animals exhibited a decreased response to pain . Unfortunately the link between the injection of IV solutions and analgesia was not recognised on any one of these occasions. Subsequently a period of respite followed together with a reduction in the use of IV injections. It is generally assumed that there was no further research involving IV-related anaesthesia until 1872 when Pierre-Cyprien Ore used IV chloral hydrate as the sole anaesthetic which was given to a total of 36 surgical patients Sykes 1960 . Unfortunately because of the high incidence of mortality linked to Ore s technique there was little further interest and the idea of using the venous system to deliver anaesthesia was dismissed until the late nineteenth century. Recent research into veterinary anaesthesia has discovered that almost half a century before Ore s work was published M. Dupy Director of the Toulouse Veterinary School had begun to use the external jugular veins of horses to administer IV chemical compounds such as alcohol. Dupy noted among other things that the expired air smelt strongly of alcohol Anonymous 1831 . This was the first reference to an IV substance being excreted by the lungs. The doses of alcohol that Dupy used during his experiments were not enough to render the horses unconscious just to stupefy them. If larger doses of alcohol had been used to induce unconsciousness then the link between IV induction agents and the loss of consciousness may have been established much sooner. The development of IV anaesthesia might then have taken a different course than it did at the turn of the century. As it happened the casual link between loss of consciousness and the IV injection of a drug was overlooked and the significance of studying the effects of IV .

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