tailieunhanh - Báo cáo nghiên cứu khoa học: "Đánh giá ảnh hưởng của ketamine (thuốc giảm đau) trong chăm sóc chấn thương prehospital. Một thử nghiệm lâm sàng ở Quảng Trị, Việt Nam"

Tuyển tập các nghiên cứu khoa học của trường đại học Huế đề tài: Đánh giá ảnh hưởng của ketamine (thuốc giảm đau) trong chăm sóc chấn thương prehospital. Một thử nghiệm lâm sàng ở Quảng Trị, Việt Nam. | JOURNAL OF SCIENCE Hue University N0 61 2010 EVALUATE THE EFFECTS OF KETAMINE PAIN RELIEF DRUG IN PREHOSPITAL TRAUMA CARE A CONTROLLED CLINICAL TRIAL IN QUANG TRI VIETNAM Tran Kim Phung Quang Tri Health Services SUMMARY To compare the analgesic effect and adverse events nausea vomiting of Ketamine versus Morphine analgesia to injury patients during pre-hospital evacuations. Methods Patients injured in one sector get Ketamine relief treatment group . Patients from the other sector get Morphine controlled group . Patients actual pain was assessed and rated on VAS. The difference VAS1-VAS2 is the indicator of analgesic effect. Adverse effect nausea vomiting based on clinical assessment at the end point and interview. Results 257 patients included of which 140 in Ketamine and 117 in Morphine was analysed. Significant difference between VAS1-VAS2 p . No significant difference of analgesic effect between Ketamine and Morphine group p . Analgesic effect of Ketamine is very clear in every ISS level regardless of male female and age groups. Conclusions Analgesic effect of Ketamine in trauma care at community is clear the same analgesic effect of Morphine. Adverse effect nausea vomiting is much lower in Ketamine than Morphine. Key words Analgesic effect adverse events pre - hospital. 1. Introduction Efficient pain relief is crucial in primary life support for trauma victims. Acute pain makes breathing efforts inefficient and thereby adversely affects oxygenation. Persistent pain and anxiety also trigger post injury release of catecholamines and cortisol and thus accelerate a post-injury stress response and aggravate immunosuppression. Uncontrolled post-injury stress response is a heavy risk factor for trauma death. In most pre - hospital trauma systems opioid analgesics have been the analgesics of choice for the last few decades. These are potent analgesics however they are not without potentially fatal side - effects. Evacuations are often rough and difficult in .