tailieunhanh - Báo cáo khoa học: " Bench-to-bedside review: Brain-lung interaction in the critically ill - a pending issue revisited"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Brain-lung interaction in the critically ill - a pending issue revisited. | Available online http content 11 3 216 Review Bench-to-bedside review Brain-lung interaction in the critically ill - a pending issue revisited Romina Gonzalvo Octavi Martí-Sistac Lluís Blanch and Josefina Lopez-Aguilar Critical Care Center Hospital de Sabadell Institut Universitari Fundacio Parc Taulí-Universitat Autónoma de Barcelona Barcelona Spain Corresponding author Lluís Blanch lblanch@ Published 14 June 2007 This article is online at http content 11 3 216 2007 BioMed Central Ltd Critical Care 2007 11 216 doi cc5930 Abstract Brain and or lung injury is the most frequent cause of admission to critical care units and patients in this setting frequently develop multiple organ dysfunction with high rates of morbidity and mortality. Mechanical ventilation is commonly used in the management of these critically ill patients and the consequent inflammatory response together with other physiological factors is also thought to be involved in distal organ dysfunction. This peripheral imbalance is based on a multiple-pathway cross-talk between the lungs and other organs including the brain. Interestingly acute respiratory distress syndrome survivors frequently present some cognitive deterioration at discharge. Such neurological dysfunction might be a secondary marker of injury and the neuroanatomical substrate for downstream impairment of other organs. Brain-lung interactions have received little attention in the literature but recent evidence suggests that both the lungs and brain are promoters of inflammation through common mediators. This review addresses the current status of evidence regarding brain-lung interactions their pathways and current interventions in critically ill patients receiving mechanical ventilation. Introduction Critically ill patients frequently develop multiple organ dysfunction syndrome 1 2 independently of the nature of the original disease. Mechanical ventilation is often an indispensable part of life .