tailieunhanh - Báo cáo khoa học: "Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Metabolic effects of phosphodiesterase III inhibitors: another reason to promote their use? | Available online http content 11 3 139 Commentary Metabolic effects of phosphodiesterase III inhibitors another reason to promote their use Vladislava Simkova1 2 Peter Radermacher1 and Eberhard Barth1 1Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung Universitatsklinikum Parkstrasse 11 D-89073 Ulm Germany 2Anesteziologicko-resuscitacni klinika Fakultni nemocnice u sv Anny Brno Czech Republic Corresponding author Peter Radermacher Published 11 June 2007 This article is online at http content 11 3 139 2007 BioMed Central Ltd Critical Care 2007 11 139 doi cc5924 See related research by Heringlake et al. http content 11 2 R51 Abstract Phosphodiesterase III inhibitors combine positive inotropic and vasodilator properties. These inhibitors are therefore frequently used to treat low cardiac output and or severe left heart failure associated with cardiac surgery. Their effects on energy metabolism and visceral organ function are not well studied however particularly in comparison with their competitors in daily practice that is catecholamines . In the previous issue of Critical Care Heringlake and colleagues compared the metabolic and renal effects of adrenaline and the phosphodiesterase III inhibitor milrinone in patients with low cardiac output after coronary artery bypass surgery 1 . Demographic data of the study population the cardiopulmonary bypass time and baseline hemodynamics were well matched. Adrenaline or milrinone were randomly administered to achieve a cardiac index 3 l min m2 and were maintained thereafter for the 14-hour study period. Patients without the need for inotropic support served as controls. Despite comparable hemodynamics blood lactate pyruvate and glucose concentrations were higher in the adrenaline-treated patients the latter being affiliated with higher exogenous insulin requirements. This metabolic pattern was accompanied with transitory higher .