tailieunhanh - Báo cáo khoa học: "Caudwell Xtreme Everest: a field study of human adaptation to hypoxia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Caudwell Xtreme Everest: a field study of human adaptation to hypoxia. | Available online http content 11 4 151 Commentary Caudwell Xtreme Everest a field study of human adaptation to hypoxia Mike Grocott1 Alan Richardson2 Hugh Montgomery1 and Monty Mythen1 Centre for Altitude Space and Extreme Environment Medicine CASE Medicine UCL Institute of Human Health and Performance Ground Floor Charterhouse Building UCL Archway Campus Highgate Hill London N19 5LW UK 2Chelsea School University of Brighton Hillbrow Denton Road Eastbourne BN20 7SR UK Corresponding author Monty Mythen montymythen@ Published 1 August 2007 This article is online at http content 11 4 151 2007 BioMed Central Ltd Critical Care 2007 11 151 doi cc5921 Abstract Caudwell Xtreme Everest CXE is a large healthy volunteer field study investigating human adaptation to environmental hypoxia. More than 200 individuals were studied at sea-level and in four laboratories on the trek to Everest Base Camp 5 300 m . Fifteen physicians climbed high on Everest and continued the studies as they ascended eight of these individuals reached the summit of Everest and succeeded in sampling arterial blood at 8 400 m on their descent. Core measurements included cardiopulmonary exercise testing neuropsychological assessment near infra-red spectroscopy of brain and exercising muscle blood markers and daily recording of simple physiological variables. The goal of CXE is to further our understanding of human adaptation to cellular hypoxia a fundamental mechanism of injury in critical illness with the aim of improving the care of critically ill patients. Caudwell Xtreme Everest CXE is a large healthy volunteer field study investigating human adaptation to environmental hypoxia 1 . The project is organised by the Centre for Altitude Space and Extreme Environment Medicine CASE Medicine at University College London. During April and May 2007 more than 200 individuals were studied as they were progressively exposed to hypobaric hypoxia on the trek to Everest .