tailieunhanh - báo cáo khoa học: " Current standards for the storage of human samples in biobanks"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Current standards for the storage of human samples in biobanks | Peakman and Elliott Genome Medicine 2010 2 72 http content 2 10 72 w Genome Medicine COMMENTARY L__ Current standards for the storage of human samples in biobanks Tim Peakman 1 and Paul Elliott 2 Abstract Biobanks are diverse in their design and purpose the idea of fully harmonizing historical and future biobanks is unaffordable and unfeasible. Biobanks should focus their efforts instead on developing and maintaining high-quality collections of samples capable of providing a wide range of biological information using processes that minimize introduced variability. A full data audit trail on sample processing archiving and quality control procedures should also be provided. This should enable the data derived from biobanks to contribute as part of wider collaborative efforts with other similar resources. Biobanks the need for standardization Biobanks are heterogeneous in their design and use and they range in size from say 1 000 patients to 500 000 or more volunteers. They may contain data and samples from family studies or from patients with a specific disease plus ideally matched controls or they may be part of large-scale epidemiologic collections or collections from clinical trials of new medical interventions. The samples collected will typically include whole blood and its fractions extracted genomic DNA whole cell RNA urine as well as variously saliva nail clippings hair and a variety of other tissues and material relevant to the design of specific studies. Inevitably data and samples are collected under different conditions to different standards and for different purposes. Some biobanks take a highly centralized approach to the collection processing and archiving of samples for example UK Biobank 1 where participant samples undergo minimal processing at the collection site but are shipped to a central Equal contributors Correspondence 2MRC-HPA Centre for Environment and Health Department of Epidemiology .