tailieunhanh - báo cáo khoa học: " Recent insights into the role of NF-κB in ovarian carcinogenesis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Recent insights into the role of NF-κB in ovarian carcinogenesis | Alvero Genome Medicine 2010 2 56 http content 2 8 56 w Genome Medicine MINIREVIEW L__ Recent insights into the role of NF-kB in ovarian carcinogenesis Ayesha B Alvero Abstract The NF-kBs are a family of ubiquitously expressed transcription factors that have been described to be responsible for the establishment of an inflammatory response. Studies in the past decade have also demonstrated this family s role in the initiation and progression of hematological and solid tumors. Recently research has uncovered a specific role for NF-kBs in the development and maintenance of ovarian cancer. Clinical overview of epithelial ovarian cancer Epithelial ovarian cancer EOC accounts for the majority of ovarian cancer and is the most lethal of all gynecological malignancies. It was expected that 21 550 new cases of EOC would be diagnosed in the US in 2009 and that 14 600 women would die from the disease 1 . Although ovarian cancer accounts for only 3 of all female cancers it is the fifth most common cause of cancer deaths in women. Given that EOC usually presents with non-specific symptoms such as bloating or abdominal discomfort which can all be mistaken for a more benign condition and because there is currently no means for early detection patients with EOC are often diagnosed with late-stage disease International Federation of Gynecology and Obstetrics FIGO stage III or IV . On initial diagnosis patients undergo complete surgical debulking resection whose only goal is to make subsequent therapy more effective followed by combination chemotherapy usually consisting of carboplatin and paclitaxel. Approximately 80 of patients respond to this treatment regimen which has been the standard for more than 10 years 2 . However 60 to 80 of the responders present with recurrent disease between 6 months and 2 years after treatment. Unfortunately disease Correspondence Department of Obstetrics Gynecology and Reproductive Sciences Yale .