tailieunhanh - báo cáo khoa học: " Shared pathways to infectious disease susceptibility?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Shared pathways to infectious disease susceptibility? | Khor and Hibberd Genome Medicine 2010 2 52 http content 2 8 52 w Genome Medicine COMMENTARY L__ Shared pathways to infectious disease susceptibility Chiea C Khor1 2 and Martin L Hibberd 1 2 Abstract The recent advent of genomic approaches for association testing is starting to enable a more comprehensive understanding of the role of human immune response in determining infectious disease outcomes. Progressing from traditional linkage approaches using microsatellite markers to high-resolution genome-wide association scans these new approaches are leading to the robust discovery of a large number of disease susceptibility genes and the beginnings of an appreciation of their connections. In this commentary we discuss how this technology development has led to increasingly complex and common infectious diseases being unraveled and how this is starting to dissect pathogen-specific human responses. Intriguingly these still preliminary findings suggest that pathogen innate detection mechanisms may not be as shared among diseases as immune response mechanisms. Introduction Many severe diseases resulting from infections such as meningitis dengue or leprosy are relatively rare within the human population when compared with the often ubiquitous nature of the causative infectious agent in specific world regions. While antibody responses to these organisms can be measured in large percentages of these populations disease leading to hospitalization affects a small minority. This has led to the realization that the type of host response made to an infectious encounter may play a large role in determining the outcome. Understanding how most people successfully contain these infectious challenges may lead to the development of novel therapeutics for those individuals at risk of severe disease. Correspondence hibberdml@ infectious Diseases Genome Institute of Singapore 60 Biopolis Street 02-01 Genome 138672 Singapore. 2Department of .