tailieunhanh - báo cáo khoa học: " Serotonin transporter polymorphisms and panic disorder"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Serotonin transporter polymorphisms and panic disorder | Schumacher and Deckert Genome Medicine 2010 2 40 http content 2 6 40 Genome Medicine MINIREVIEW L__ Serotonin transporter polymorphisms and panic disorder Johannes Schumacher1 and Jurgen Deckert2 Abstract Panic disorder PD is the most common anxiety disorder. Although PD seems to occur unprovoked and the underlying etiology is not well understood studies have consistently shown that genetic factors explain approximately 48 of the variance. Moreover family and twin studies support the view that the majority of PD cases have a complex genetic basis. Promising findings have most recently implicated the polymorphisms at the 3 end of the serotonin transporter gene SLC6A4 as PD risk variants. If independent studies can replicate the observed association with the SLC6A4 variants and their functional effects on gene expression this would have a great impact on our understanding of the disease pathophysiology and would provide opportunities to investigate genotype-phenotype correlations. The genetics of panic disorder Panic disorder PD has a population prevalence of to and is the most common anxiety disorder 1 2 . According to the American Psychiatric Association PD is defined as an episode of abrupt intense fear accompanied by additional physiological or cognitive symptoms. Other anxiety disorders and also mood and substance-use disorders are frequently observed as comorbidities 3 4 . Family and twin studies have consistently shown that genetic factors explain approximately 48 of the variance in the disease 5 and segregation analyses support the view that the majority of PD cases have a complex genetic basis. This is also highlighted by several animal breeding experiments which reveal that anxiety or emotional activity analogous to panic and anxiety is controlled by multiple genes possibly in Correspondence Deckert_J@ department of Psychiatry Psychosomatics and Psychotherapy University of Wurzburg Fuchsleinstrasse

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