tailieunhanh - Báo cáo khoa học: "High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis: a prospective study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis: a prospective study. | Available online http content 11 2 R32 Research High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis a prospective study Shahin Gaini1 Svend Stenvang Pedersen1 Ole Gr sboll Koldkj r2 Court Pedersen1 and Holger Jon Moller3 Department of Infectious Diseases Odense University Hospital Sondre Boulevard 29 DK-5000 Odense C Denmark 2Department of Clinical Biochemistry Sonderborg Hospital Sydvang 1 DK-6400 Sonderborg Denmark 3Department of Clinical Biochemistry Aarhus University Hospital Norrebrogade 44 DK-8000 Aarhus C Denmark Corresponding author Shahin Gaini Received 29 Dec 2006 Revisions requested 7 Feb 2007 Revisions received 16 Feb 2007 Accepted 8 Mar 2007 Published 8 Mar 2007 Critical Care 2007 11 R32 doi cc5715 This article is online at http content 11 2 R32 2007 Gaini et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Sepsis is a serious condition with a significant morbidity and mortality. New insight into the immunopathogenesis of sepsis could promote the development of new strategies for diagnosis and therapy. High mobility group box-1 protein HMGB1 has been known for many years as a nuclear chromosomal protein. Its role as a pro-inflammatory cytokine in sepsis and rheumatoid arthritis has been described recently. The aim of our study was to evaluate HMGB1 as a molecular marker in patients with community-acquired infections. Methods Patients suspected of having infections sepsis and admitted to a department of internal medicine were included in the study in a prospective manner. Demographic data comorbidity routine biochemistry microbiological data infection focus severity

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