tailieunhanh - Báo cáo khoa học: "Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Case report: quantification of methadone-induced respiratory depression using toxicokinetic/toxicodynamic relationships. | Available online http content 11 1 R5 Research Case report quantification of methadone-induced respiratory depression using toxicokinetic toxicodynamic relationships Bruno Mégarbane1 2 Xavier Declèves2 Vanessa Bloch1 2 Christophe Bardin3 Franpois Chast3 and Frédéric J Baud1 2 1INSERM U705 CNRS UMR 7157 Université Paris 7 Assistance Publique - Hôpitaux de Paris Hôpital Lariboisière Réanimation Médicale et Toxicologique 2 Rue Ambroise Paré 75010 Paris France 2INSERM U705 CNRS UMR 7157 Université Paris 7 Assistance Publique - Hôpitaux de Paris Hôpital Fernand Widal 200 Rue du Faubourg Saint Denis 75018 Paris France Assistance Publique - Hôpitaux de Paris Hôpital Hôtel-Dieu Laboratoire de Toxicologie 1 Place Notre-Dame 75004 Paris France Corresponding author Bruno Mégarbane bruno-megarbane@ Received 21 Sep 2006 Revisions requested 26 Oct 2006 Revisions received 28 Dec 2006 Accepted 15 Jan 2007 Published 15 Jan 2007 Critical Care 2007 11 R5 doi cc5150 This article is online at http content 11 1 R5 2007 Mégarbane et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Methadone the most widely delivered maintenance therapy for heroin addicts may be responsible for life-threatening poisonings with respiratory depression. The toxicokinetics and the toxieokinetie toxieodynamie TK TD relationships of methadone enantiomers have been poorly investigated in acute poisonings. The aim of this study was to describe the relationships between methadone-related respiratory effects and their corresponding concentrations. Methods We report a 44-year-old methadone-maintained patient who ingested a 240-mg dose of methadone. He was found comatose with pinpoint pupils and .

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