tailieunhanh - Báo cáo y học: "Metaplastic ossification in the cartilage of the bronchus of a patient with chronic multi-drug resistant tuberculosis: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Metaplastic ossification in the cartilage of the bronchus of a patient with chronic multi-drug resistant tuberculosis: a case report. | Eum et al. Journal of Medical Case Reports 2010 4 156 http content 4 1 156 Ws CASE REPORTS CASE REPORT Open Access Metaplastic ossification in the cartilage of the bronchus of a patient with chronic multi-drug resistant tuberculosis a case report Seok-Yong Eum 1 Ji-Hye Kong1 Bo-Young Jeon2 Sang-Nae Cho2 Jhingook Kim3 Laura E Via4 Clifton E Barry III4 and Won-Jung Koh3 Abstract Introduction Pulmonary ossification has been rarely observed in pulmonary fibrosis and in some chronic respiratory diseases such as chronic obstructive pulmonary disease. We report here a metaplastic ossification in the bronchial cartilage of a patient with multi-drug resistant tuberculosis. Case presentation We report the case of a 41-year-old Asian man from Korea with chronic multi-drug resistant tuberculosis with a rare focus of bone formation from the cartilage of a bronchus subtending an active cavity. The patient had a large multi-lobed thick-walled cavitary tuberculosis lesion in his left upper lobe. Severe infiltration of his lymphocytes and epithelioid cells along with some giant cells and neutrophils was observed in the patient s bronchial wall. Desquamated bronchial epithelium and acid-fast bacilli were found inside his bronchus. A small focus of bony metaplasia was found in the cartilage of his bronchial wall. Histopathological examination confirmed calcification and showed hematopoietic cells forming in his marrow cavity. Conclusions Chronic inflammation in the lungs of our patient caused by underlying tuberculosis probably played a role in the development of osseous metaplasia from the associated cartilage of the bronchial wall. Introduction Pulmonary ossification is rare and usually identified and diagnosed post-mortem by the pathologist. This phenomenon has been observed in pulmonary fibrosis and in some chronic respiratory diseases such as chronic obstructive pulmonary disease COPD 1-5 . We report here an unusual case of bone .