tailieunhanh - báo cáo khoa học: " The public health utility of genome-wide association study results for smoking behavior"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The public health utility of genome-wide association study results for smoking behavior | Furberg et al. Genome Medicine 2010 2 26 http content 2 4 26 w Genome Medicine COMMENTARY L__ The public health utility of genome-wide association study results for smoking behavior Helena Furberg 1 2 Jamie Ostroff Caryn Lerman3 and Patrick F Sullivan 2 Abstract New approaches to improve smoking cessation rates are needed. In recent years substantial progress has been made in understanding the genetics of smoking behavior and this knowledge may eventually be used to personalize treatment for smokers. Although there are highly significant and reproducible genetic associations none are yet ready for clinical applications. We suggest that translational research from several disciplines including behavioral science ethics and economics should be performed in parallel with ongoing genome-wide association studies for smoking behavior and pharmacogenetic trials. The coordinated effort of multidisciplinary research teams will help reveal the circumstances under which we can translate genetic insights into clinical practice in the hope of reducing the burden of smoking in society. Introduction Cigarette smoking is the largest preventable cause of morbidity and mortality in the world. Despite best available treatments smoking cessation remains an elusive goal for most smokers and relapse is normal. Cigarette smoking behavior is influenced in part by genetic factors 1 . Incorporating smoking-related genetic risk information into clinical practice has the potential to increase smoking cessation rates and improve public health. Here we discuss the clinical implications of emerging findings from genome-wide association studies GWASs for smoking behavior and pharmacogenetic trials of cessation treatments. We suggest that research from multiple disciplines should be conducted in parallel to bring us closer to the goal of delivering personalized cessation treatment for smokers. Correspondence FurbergA@ Department of Psychiatry and Behavioral .