tailieunhanh - Báo cáo y học: " The use of tacrolimus for recurrent lupus enteritis: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The use of tacrolimus for recurrent lupus enteritis: a case report. | Shirai et al. Journal of Medical Case Reports 2010 4 150 http content 4 1 150 CASE REPORTS CASE REPORT Open Access Theuse of tacrolimus for recurrent lupus enteritis a case report Tsuyoshi Shirai Yasuhiko Hirabayashi Ryu Watanabe Yumi Tajima Hiroshi Fujii Naruhiko Takasawa Tomonori Ishii and Hideo Harigae Abstract Introduction Patients with lupus enteritis sometimes experience recurrence. In such cases the addition of cyclophosphamide to the treatment regimen is recommended. However an appropriate treatment has not been established in cases where cyclophosphamide failed to prevent the disease. Case presentation An 18-year-old Japanese woman was admitted for a recurrence of lupus enteritis. One year before admission she was treated for lupus enteritis with high-dose corticosteroid together with intravenous cyclophosphamide pulse therapy. Upon admission she was administered again with high-dose corticosteroid and her abdominal pain rapidly subsided. Tacrolimus was later used as an immunosuppressive agent and a complete remission has been maintained. Conclusion Tacrolimus can be a useful agent for recurrent lupus enteritis that is resistant to conventional therapy. Introduction Patients with systemic lupus erythematosus SLE occasionally present with acute abdominal symptoms. In some cases abdominal symptoms can be the initial clinical presenting feature of SLE 1 . Lupus enteritis due to intestinal vasculitis is the most serious gastrointestinal complication of SLE presenting with acute abdominal symptoms 2 . During follow-up patients with lupus enteritis sometimes experience recurrence after experiencing complete remission with the aid of high-dose corticosteroids 3 . In such cases the addition of cyclophosphamide to the treatment regimen is recommended 4 . However an appropriate treatment has not been established in cases where cyclophosphamide failed to prevent the occurrence of the disease. Here we present the case of a