tailieunhanh - Báo cáo khoa học: "Neuromuscular deterioration in the early stage of sepsis in rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Neuromuscular deterioration in the early stage of sepsis in rats. | Available online http content 11 1 R1 Research Neuromuscular deterioration in the early stage of sepsis in rats Ilkin Cankayali1 Yusuf Hakan Dogan2 Ilhami Solak3 Kubilay Demirag1 Oguz Eris1 Serdar Demirgoren2 and Ali Resat Moral1 Open Access Department of Anaesthesiology and Intensive Care Unit Ege University School of Medicine 35100 Izmir Turkey 2Department of Physiology Ege University School of Medicine 35100 Izmir Turkey department of General Surgery Ege University School of Medicine 351 00 Izmir Turkey Corresponding author Ilkin Cankayali Received 20 Jan 2006 Revisions requested 21 Feb 2006 Revisions received 1 Sep 2006 Accepted 4 Jan 2007 Published 4 Jan 2007 Critical Care 2007 11 R1 doi cc5139 This article is online at http content 11 1 R1 2006 Cankayali et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Critical illness polyneuropathy CIP is a clinical condition frequently seen in patients being treated in critical care units in the final stage of sepsis. The etiopathology of CIP is still unclear and the onset time of appearance of the electrophysiological findings has not been elucidated. The very little research that has been carried out on this topic is limited to clinical electrophysiological and histopathological studies. In this study electrophysiological alterations in the early stage of experimentally induced sepsis were investigated in septic rats. Methods We conducted a prospective randomized controlled experimental study in an animal basic science laboratory with 30 male Sprague-Dawley rats weighing 200 to 250 g. All of the rats were randomly assigned to one of two groups. In the sepsis group n 20 cecal ligation and .