tailieunhanh - báo cáo khoa học: " Biomarkers in solid organ transplantation: establishing personalized transplantation medicine"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Biomarkers in solid organ transplantation: establishing personalized transplantation medicine | Roedder et al. Genome Medicine 2011 3 37 http content 3 6 37 Genome Medicine REVIEW Biomarkers in solid organ transplantation establishing personalized transplantation medicine Silke Roedder Matthew Vitalone Purvesh Khatri and Minnie M Sarwal Abstract Technological advances in molecular and in silica research have enabled significant progress towards personalized transplantation medicine. It is now possible to conduct comprehensive biomarker development studies of transplant organ pathologies correlating genomic transcriptomic and proteomic information from donor and recipient with clinical and histological phenotypes. Translation of these advances to the clinical setting will allow assessment of an individual patient s risk of allograft damage or accommodation. Transplantation biomarkers are needed for active monitoring of immunosuppression to reduce patient morbidity and to improve long-term allograft function and life expectancy. Here we highlight recent pre- and post-transplantation biomarkers of acute and chronic allograft damage or adaptation focusing on peripheral blood-based methodologies for non-invasive application. We then critically discuss current findings with respect to their future application in routine clinical transplantation medicine. Complement-system-associated SNPs present potential biomarkers that may be used to indicate the baseline risk for allograft damage prior to transplantation. The detection of antibodies against novel non-HLA MICA antigens and the expression of cytokine genes and proteins and cytotoxicity-related genes have been correlated with allograft damage and are potential post-transplantation biomarkers indicating allograft damage at the molecular level although these do not have clinical relevance yet. Several multi-gene expression-based biomarker panels have been identified that accurately predicted graft accommodation in liver transplant recipients and may be developed into a predictive biomarker assay. .