tailieunhanh - báo cáo khoa học: " Collaboratively charting the gene-to-phenotype network of human congenital heart defects"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Collaboratively charting the gene-to-phenotype network of human congenital heart defects | Barriot et al. Genome Medicine 2010 2 16 http content 2 3 16 w Genome Medicine DATABASE Open Access Collaboratively charting the gene-to-phenotype network of human congenital heart defects Drdian d R2rri ffi1 2 3t lor on Rro -lziffi ffi Ht RomTh l Thionrtr n1 4 5t C l 3Ìrì Rmhhcd CfiAi op qri Un Thon RcTht C tcicc ncl nold I lUDdll lot JeiUeilBieCkpUt DeH lardll liei ipoi It Sylvai IIDIUIIcc jLeVcNVdMVUUlcM DcILLUcjjcMj Leon-Charles Tranchevent Peter Van Loo -4-6 Marc Gewillig7 Koenrddd Devriendt4 and Yves Moreau CHDWiki is accessible at http bioiuser chdwiki Abstract Background How to efficiently integrate the daily practice of molecular biologists geneticists and clinicians with the emerging computational strategies from systems biology is still much of an open question. Description We built on the recent advances in Wiki-based technologies to develop a collaborative knowledge base and gene prioritization portal aimed at mapping genes and genomic regions and untangling their relations with corresponding human phenotypes congenital heart defects CHDs . This portal is not only an evolving community repository of current knowledge on the genetic basis of CHDs but also a collaborative environment for the study of candidate genes potentially implicated in CHDs - in particular by integrating recent strategies for the statistical prioritization of candidate genes. It thus serves and connects the broad community that is facing CHDs ranging from the pediatric cardiologist and clinical geneticist to the basic investigator of cardiogenesis. Conclusions This study describes the first specialized portal to collaboratively annotate and analyze gene-phenotype networks. Of broad interest to the biological community we argue that such portals will play a significant role in systems biology studies of numerous complex biological processes. Background Recently Wiki technology - inspired by the well-known Wikipedia encyclopedia - has been .