tailieunhanh - báo cáo khoa học: " Pharmacogenomics and personalized medicine: lost in translation?"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Pharmacogenomics and personalized medicine: lost in translation? | Hulot Genome Medicine 2010 2 13 http content 2 2 13 w Genome Medicine MEETING REPORT L Pharmacogenomics and personalized medicine lost in translation Jean-Sébastien Hulot Abstract A report on the Joint Cold Spring Harbor Wellcome Trust Conference Pharmacogenomics and Personalized Medicine Hinxton UK 12-15 September 2009. Introduction The Sixth Joint Cold Spring Harbor Wellcome Trust Centre Conference reported on new improvements that could affect personalized medicine for the treatment of various diseases. Even though the term pharmacogenetics was coined over 40 years ago personalized medicine has become increasingly recognized in the past few years. The basic concept is to prescribe drugs according to genetic profiles or other tests that give evidence for tailoring treatments to patients potentially improving care and saving money. It has been recognized for a long time that there is considerable inter-individual variation in the level of therapeutic responses to most drugs 1 2 and the same applies to the occurrence of adverse drug reactions. Some experts believe that most drugs currently on the market work for only a portion of the patients who take them while countless patients are exposed to useless and or toxic medications. This situation is a drawback of the one size fits all approach of conventional phase 3 studies in which the treatment that seems to be superior on average will then be recommended for all patients with the same disease. This is a global rather than individual evaluation that determines the best treatment for a group of patients without distinguishing the fortunate few who will really benefit from it. Genome-wide association studies a new paradigm for pharmacogenomics Although individualization of certain treatments had been carried out in the pre-genomic era recent progress Correspondence Cardiovascular Research Center Mount Sinai School of Medicine One Gustave L Levy Place Box 1030 New