tailieunhanh - Báo cáo khoa học: "Microcirculatory alterations induced by sedation in intensive care patients. Effects of midazolam alone and in association with sufentanil"

Available online Research Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Microcirculatory alterations induced by sedation in intensive care patients. Effects of midazolam alone and in association with sufentanil. | Available online http content 10 6 R176 Research Microcirculatory alterations induced by sedation in intensive care patients. Effects of midazolam alone and in association with sufentanil Veronique Lamblin Raphael Favory Marie Boulo and Daniel Mathieu Service d Urgence Respiratoire et Réanimation Médicale et de Médecine Hyperbare Hôpital Calmette Centre Hospitalier Universitaire Boulevard du Professeur Jules Leclercq 59037 Lille Cedex France Corresponding author Daniel Mathieu dmathieu@ Received 16 Jun 2006 Revisions requested 5 Jul 2006 Revisions received 29 Aug 2006 Accepted 15 Dec 2006 Published 15 Dec 2006 Critical Care 2006 10 R176 doi cc5128 This article is online at http content 10 6 R1 76 2006 Lamblin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Sedation is widely used in intensive care unit ICU patients to limit the risk of pulmonary barotrauma and to decrease oxygen needs. However adverse effects of sedation have not been fully evaluated in particular effects of benzodiazepine and opiates on microcirculation have not been extensively studied. The aim of this study was to evaluate the microcirculatory effects of a sedation protocol commonly prescribed in the ICU. Methods Ten non-septic patients under controlled ventilation requiring sedation for therapeutic purposes were enrolled in a prospective observational study conducted in an ICU of a university hospital. Sedation was conducted in two successive steps first each patient received midazolam mg kg per hour after a bolus of mg kg then adapted to reach a Ramsay score of between 3 and 5 . Second after one hour sufentanil was added pg kg per hour after a bolus of .

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