tailieunhanh - Báo cáo khoa học: "Bench-to-bedside review: Potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure. | Available online http content 10 5 228 Review Bench-to-bedside review Potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure Alessandro Protti1-2 and Mervyn Singer1 1 Bloomsbury Institute of Intensive Care Medicine- Wolfson Institute for Biomedical Research and Department of Medicine- University College London-London- UK 2Istituto di Anestesia e Rianimazione- Ospedale Maggiore Policlinico- Mangiagalli e Regina Elena - IRCCS- Milan- Italy Corresponding author Mervyn Singer- Published 1 September 2006 This article is online at http content 10 5 228 2006 BioMed Central Ltd Critical Care 2006- 10 228 doi cc5014 Abstract The pathogenesis of sepsis-induced multiple organ failure may crucially depend on the development of mitochondrial dysfunction and consequent cellular energetic failure. According to this hypothesis- interventions aimed at preventing or reversing mitochondrial damage may have major clinical relevance- although the timing of such interventions will be critical to both ensuring benefit and avoiding harm. Early correction of tissue hypoxia- strict control of glycaemia- and modulation of oxidative and nitrosative stress may afford protection during the initial- acute systemic inflammatory response. The regulated induction of a hypometabolic state resembling hibernation may protect the cells from dying once energy failure has developed- allowing the possibility of functional recovery. Repair of damaged organelles through stimulation of mitochondrial biogenesis and reactivation of cellular metabolism may accelerate resolution of the multiple organ failure syndrome. Introduction Sepsis is the systemic inflammatory response to infection and represents a major cause of morbidity and mortality in patients admitted to intensive care units ICUs 1 . However- despite decades of research- the pathophysiology of sepsis remains incompletely understood. A critical limitation