tailieunhanh - Báo cáo khoa học: " Liver dysfunction after lung recruitment manoeuvres during pressure-controlled ventilation in experimental acute respiratory distress"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Liver dysfunction after lung recruitment manoeuvres during pressure-controlled ventilation in experimental acute respiratory distress. | Available online http content 11 1 R13 Research Liver dysfunction after lung recruitment manoeuvres during pressure-controlled ventilation in experimental acute respiratory distress Markus Kredel1 Ralf M Muellenbach1 Robert W Brock2 Hans-Hinrich Wilckens1 Joerg Brederlau1 Norbert Roewer1 and Christian Wunder1 University of Wurzburg Department of Anaesthesiology University Hospital Wurzburg Oberdurrbacherstr. 6 97080 Wurzburg Germany 2University of Arkansas for Medical Sciences Department of Pharmacology and Toxicology 4301 Markham St. Little Rock AR USA Contributed equally Corresponding author Markus Kredel kredel_m@ Received 20 Sep 2006 Revisions requested 14 Nov 2006 Revisions received 6 Dec 2006 Accepted 29 Jan 2007 Published 29 Jan 2007 Critical Care 2007 11 R13 doi cc5674 This article is online at http content 11 1 R13 2007 Kredel et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Consequences of lung recruitment with prolonged high positive end-expiratory pressure PEEP ventilation for liver function are unclear. We therefore investigated liver dysfunction during two different ventilation treatment regimens of experimental acute respiratory distress syndrome. Methods Sixteen anaesthetised juvenile pietrain pigs were ventilated in the pressure-controlled mode PCV with an inspiratory fraction of oxygen FiO2 of a respiratory frequency of 30 per minute a tidal volume of 6 ml kg and a PEEP of 5 cm H2O. After lung injury was induced by repeated pulmonary lavage with normal saline animals were randomly assigned into two groups n 8 each for a 24-hour trial PCV unchanged ventilation and PCV with recruitment PCV R starting with a .

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