tailieunhanh - báo cáo khoa học: " Secretome: clues into pathogen infection and clinical applications"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Secretome: clues into pathogen infection and clinical applications | Genome Medicine Review Secretome clues into pathogen infection and clinical applications Shoba Ranganathan and Gagan Garg Addresses Department of Chemistry and Biomolecular Sciences and ARC Centre of Excellence in Bioinformatics Macquarie University Sydney NSW 2109 Australia. Department of Biochemistry Yong Loo Lin School of Medicine National University of Singapore 8 Medical Drive 117597 Singapore. Correspondence Shoba Ranganathan. Email Abstract The secretome encompasses the complete set of gene products secreted by a cell. Recent studies on secretome analysis reveal that secretory proteins play an important role in pathogen infection and host-pathogen interactions. Excretory secretory proteins of pathogens change the host cell environment by suppressing the immune system to aid the proliferation of infection. Identifying secretory proteins involved in pathogen infection will lead to the discovery of potential drug targets and biomarkers for diagnostic applications. Introduction The secretome constitutes the entire set of secreted proteins representing up to 30 of the proteome of an organism 1 and includes functionally diverse classes of molecules such as cytokines chemokines hormones digestive enzymes antibodies extracellular proteinases morphogens toxins and antimicrobial peptides. Some of these proteins are involved in a host of diverse and vital biological processes including cell adhesion cell migration cell-cell communication differentiation proliferation morphogenesis survival and defense virulence factors in bacteria and immune responses 2 . Excretory secretory proteins ESPs circulating throughout the body of an organism for example in the extracellular space are localized to or released from the cell surface making them readily accessible to drugs and or the immune system. These characteristics make these molecules extremely attractive targets for novel vaccines and therapeutics which are currently the focus of major drug .