tailieunhanh - báo cáo khoa học: " Musings on genome medicine: Crohn’s disease"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Musings on genome medicine: Crohn’s disease | Genome Medicine Musings Musings on genome medicine Crohn s disease David G Nathan and Stuart H Orkin Address Dana-Farber Cancer Institute 44 Binney Street Boston MA 02115 USA. Correspondence David G Nathan. Email david_nathan@ Abstract The inflammatory bowel diseases Crohn s disease and ulcerative colitis pose a fascinating challenge to specialists in gastroenterology infectious diseases immunology and genetics and an often crushing burden to patients and their families. Approximately a half million children and adults deal with Crohn s disease CD in North America for a prevalence of about 170 100 000 1 while the prevalence averages about 40 100 000 in Europe 2 . Curiously the prevalence and incidence are higher in the northern parts of Europe and North America than in the southern parts 2 . There are well-established risk factors for CD including being Ashkenazi Jewish having a first-degree relative with CD stress and smoking. Although there is female predominance in Canada Europe and the United States report a small excess of males 2 . The incidence is much higher in developed than in less developed countries leading to an hypothesis that improved hygiene may influence the onset of the disease. This concept has led to interesting experiments in which helminths are deliberately fed to patients with CD 3 4 . Crohn s disease was described first in 1904 by a Polish surgeon Antoni Lesniowski 5 and more thoroughly by Burrill Crohn and his colleagues at the Mount Sinai Hospital of New York in 1932 6 . The clinical presentation of CD and its pathology differs from that of ulcerative colitis UC in that the former may be far more widespread throughout the gastrointestinal tract may extend deeply into the intestinal wall is associated with granuloma formation and is characterized by skip areas. Hence the original and now unused name regional enteritis . It tends to localize in the terminal ileum where it may narrow the bowel and cause malabsorption of .

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