tailieunhanh - Báo cáo khoa học: "Luminal concentrations of L- and D-lactate in the rectum may relate to severity of disease and outcome in septic patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Luminal concentrations of L- and D-lactate in the rectum may relate to severity of disease and outcome in septic patients. | Available online http content 10 6 R163 Research Luminal concentrations of L- and D-lactate in the rectum may relate to severity of disease and outcome in septic patients Vibeke L Jorgensen1 Nanna Reiter2 and Anders Perner2 Department of Anaesthesia and Intensive Care Herlev Hospital Herlev Ringvej 75 DK-2730 Herlev Denmark department of Intensive Care Rigshospitalet University of Copenhagen Blegdamsvej DK-21 00 Copenhagen 0 Denmark Corresponding author Anders Perner ap@ Received 8 Jul 2006 Revisions requested 2 Aug 2006 Revisions received 29 Aug 2006 Accepted 20 Nov 2006 Published 20 Nov 2006 Critical Care 2006 10 R163 doi cc5102 This article is online at http content 10 6 R163 2006 Jorgensen et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Little is known about the condition of the large bowel in patients with sepsis. We have previously demonstrated increased concentrations of L-lactate in the rectal lumen in patients with abdominal septic shock. The present study was undertaken to assess the concentrations of L- and D-lactate in rectal lumen and plasma in septic patients including the possible relation to site of infection severity of disease and outcome. Methods An intensive care unit observational study was conducted at two university hospitals and 23 septic patients and 11 healthy subjects were enrolled. Participants were subjected to rectal equilibrium dialysis and concentrations of Land D-lactate in dialysates and plasma were analysed by spectrophotometry. Results Luminal concentrations of L-lactate in rectum were related to the sequential organ failure assessment scores R2 P and were higher in non-survivors compared to .