tailieunhanh - Báo cáo hóa học: " A Genetic Programming Method for the Identification of Signal Peptides and Prediction of Their Cleavage Sites David Lennartsson"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: A Genetic Programming Method for the Identification of Signal Peptides and Prediction of Their Cleavage Sites David Lennartsson | EURASIP Journal on Applied Signal Processing 2004 1 138-145 2004 Hindawi Publishing Corporation A Genetic Programming Method for the Identification of Signal Peptides and Prediction of Their Cleavage Sites David Lennartsson Saida Medical AB Stena Center 1A SE-412 92 Goteborg Sweden Email Peter Nordin Department of Physical Resource Theory Chalmers University of Technology SE-412 96 Goteborg Sweden Email Received 28 February 2003 Revised 31 July 2003 A novel approach to signal peptide identification is presented. We use an evolutionary algorithm for automatic evolution of classification programs so-called programmatic motifs. The variant of evolutionary algorithm used is called genetic programming where a population of solution candidates in the form of full computer programs is evolved based on training examples consisting of signal peptide sequences. The method is compared with a previous work using artificial neural network ANN approaches. Some advantages compared to ANNs are noted. The programmatic motif can perform computational tasks beyond that of feedforward neural networks and has also other advantages such as readability. The best motif evolved was analyzed and shown to detect the h-region of the signal peptide. A powerful parallel computer cluster was used for the experiment. Keywords and phrases signal peptides genetic programming bioinformatics programmatic motif artificial neural networks cleavage site. 1. INTRODUCTION The huge and growing amount of unanalyzed data present in genetic research creates a demand for automatic methods for classification of proteins and protein properties. Automatic mechanical means for property screening of interesting proteins would accelerate the process of finding new drug candidates. Classification rules for the processing of amino acid sequences can be obtained either by human design or by a mechanical process the latter often through the use of .

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