tailieunhanh - Báo cáo khoa học: "Growth arrest-specific protein 6 plasma concentrations during septic shock"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Growth arrest-specific protein 6 plasma concentrations during septic shock. | Available online http content 11 1 R8 Research Growth arrest-specific protein 6 plasma concentrations during septic shock Sébastien Gibot1-2 Frédéric Massin3 Aurélie Cravoisy1 Rachel Dupays1 Damien Barraud1 Lionel Nace1 and Pierre-Edouard Bollaert1 Service de Réanimation Médicale Avenue du Maréchal de Lattre de Tassigny Hôpital Central Nancy 54000 France 2Projet Avenir INSERM Coordination Circulation 3Laboratoire d lmmunologie Avenue de la Foret de Haye Faculté de Médecine Nancy 54000 France Corresponding author Sébastien Gibot Received 13 Nov 2006 Revisions requested 18 Dec 2006 Revisions received 1 Jan 2007 Accepted 22 Jan 2007 Published 22 Jan 2007 Critical Care 2007 11 R8 doi cc5158 This article is online at http content 11 1 R8 2007 Gibot et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The product of growth arrest-specific gene 6 Gas6 is a vitamin K dependent protein that is secreted by leucocytes and endothelial cells in response to injury and participates in cell survival proliferation migration and adhesion. Our purpose was to investigate plasma Gas6 concentration and its relation to organ dysfunction in patients with septic shock. Methods Forty-five patients with septic shock admitted to a medical adult intensive care unit were enrolled. Plasma Gas6 concentration was determined using enzyme-linked immunosorbent assay at days 1 3 7 and 14. Results The median interquartile range Gas6 concentration was 51 5 to 95 pg ml at admission. A positive correlation Spearman rank-order coefficient rs P was found between Gas6 level and Sepsis-related Organ Failure Assessment score. Patients requiring renal support had higher .