tailieunhanh - Báo cáo khoa học: "Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients: a prospective cohort study. | Available online http content 10 5 R142 Research Epidemiology and clinical outcome of virus-positive respiratory samples in ventilated patients a prospective cohort study Cédric Daubin1 Jean-Jacques Parienti2 3 Sophie Vincent1 Astrid Vabret4 Damien du Cheyron1 Michel Ramakers1 Franqois Freymuth4 and Pierre Charbonneau1 Department of Medical Intensive Care Avenue Côte de Nacre Caen University Hospital 1 4033 Caen Cedex France 2Department of Biostatistics and Clinical Research Avenue Côte de Nacre Caen University Hospital 14033 Caen Cedex France 3Inserm UMR-S 707 Université Pierre et Marie Curie-Paris6 UMR-S 707 Paris F-75012 France 4Department of Virology Avenue Côte de Nacre Caen University Hospital 14033 Caen Cedex France Corresponding author Cédric Daubin daubin-c@ Received 14 Jul 2006 Revisions requested 10 Aug 2006 Revisions received 19 Sep 2006 Accepted 5 Oct 2006 Published 5 Oct 2006 Critical Care 2006 10 R142 doi cc5059 This article is online at http content 10 5 R1 42 2006 Daubin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Respiratory viruses are a major cause of respiratory tract infections. The prevalence of a virus-positive respiratory sample and its significance in patients requiring mechanical ventilation remain unknown. Methods We conducted a cohort study in all consecutive adults ventilated for more than 48 hours admitted to a 22-bed medical intensive care unit during a 12-month period. Respiratory samples at the time of intubation were assessed by culture by indirect immunofluorescence assay or by molecular methods in systematic tracheobronchial aspirates. Patients with a virusnegative respiratory sample at the time of .