tailieunhanh - Báo cáo khoa học: "Statins, bugs and prophylaxis: intriguing possibilities"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Statins, bugs and prophylaxis: intriguing possibilities. | Available online http content 10 5 168 Commentary Statins bugs and prophylaxis intriguing possibilities Marius Terblanche1 Terry S Smith2 and Neill KJ Adhikari2 1 Department of Critical Care Medicine St Thomas Hospital Lambeth Palace Road London SE1 7EH UK interdepartmental Division of Critical Care Medicine University of Toronto and Department of Critical Care Medicine Sunnybrook Health Sciences Centre 2075 Bayview Avenue Toronto Canada M4N 3M5 Corresponding author Marius Terblanche Published 27 October 2006 Critical Care 2006 10 168 doi cc5056 This article is online at http content 10 5 168 2006 BioMed Central Ltd Abstract Statin therapy may represent a potential prophylactic intervention in certain high-risk scenarios for example in pandemic influenza and in those undergoing aggressive medical treatments. Emerging data indicate a potential prophylactic role in these high-risk groups. Introduction Prophylaxis is defined as preventive treatment against disease . A prophylactic measure that dampens the systemic response to infection or physiologic stress and has direct effects against the trigger of that response could greatly reduce the burden of illness associated with critical illness. Numerous clinical trials have provided unequivocal evidence that statins are safe and effective in preventing cardiovascular morbidity and mortality and many statin-associated benefits are considered to stem from effects other than lipid modulation 1 2 . Intriguingly observations indicate that statins may also directly affect the infectivity and proliferation of some microorganisms. Viruses Statins decrease viral loads and increase CD4 cell counts in an in vivo model of acute HIV-1 infection 3 . Changes in Rho-controlled actin cytoskeleton rearrangements inhibit HIV-1 entry into and exit from host cells. Furthermore many statins directly block the interaction between intercellular adhesion molecule ICAM -1 and leukocyte

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