tailieunhanh - Báo cáo y học: " The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting: two case reports | Jaeckel et al. Journal of Medical Case Reports 2010 4 82 http content 4 1 82 jAl JOURNALOF medical ÌỤr case REPORTS CASE REPORT Open Access The use of partial exchange blood transfusion and anaesthesia in the management of sickle cell disease in a perioperative setting two case reports Rhett Jaeckel Matthias Thieme Elke Czeslick Armin Sablotzki Abstract Introduction Homozygous sickle cell carriers have an increased perioperative mortality. Some indications may justify an exchange blood transfusion to reduce the proportion of haemoglobin S. The advantages of general blood transfusion in a perioperative setting have not been proven and thus remain controversial. It is not clear whether reducing the proportion of haemoglobin S minimizes perioperative complications or whether patients with sickle cell disease in a stable clinical condition benefit from an exchange blood transfusion in a perioperative setting. Case presentation We report the case of two Angolan children aged 10 and 11 respectively of African origin with sickle cell anaemia who underwent surgery to treat chronic necrosis fistula of the bones and bone destruction. This presentation describes the perioperative course including general anaesthesia. A partial exchange blood transfusion decreased S-haemoglobin levels from 81 to 21 and simultaneously treated the anaemia. Conclusion There is a consensus that imbalances in homoeostasis including operative procedures can cause a critical exacerbation of sickle cell disease. The case presented here illustrates a strategy for successfully managing sickle cell disease in the perioperative period to minimize its complications. It is important for the anaesthesiologist to carefully manage pulmonary gas exchange and to ensure sufficient tissue perfusion balanced fluid resuscitation and normothermia while keeping in mind the level of organ impairment in order to prevent an acute exacerbation of sickle cell disease. We performed a partial .

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