tailieunhanh - Báo cáo khoa học: "ntravenous nitroglycerin does not preserve gastric microcirculation during gastric tube reconstruction: a randomized controlled trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: ntravenous nitroglycerin does not preserve gastric microcirculation during gastric tube reconstruction: a randomized controlled trial. | Available online http content 10 5 R131 Research Intravenous nitroglycerin does not preserve gastric microcirculation during gastric tube reconstruction a randomized controlled trial Marc Buise1 Jasper van Bommel1 2 Alexander Jahn1 KheTran3 Huug Tilanus3 and Diederik Gommers1 2 Department of Anesthesiology Erasmus MC Rotterdam Gravendijkwal 3015 CE Rotterdam The Netherlands 2Department of Intensive Care Erasmus MC Rotterdam Gravendijkwal 3015 CE Rotterdam The Netherlands 3Department of Surgery Erasmus MC Rotterdam Gravendijkwal 3015 CE Rotterdam The Netherlands Corresponding author Diederik Gommers Received 26 Jun 2006 Revisions requested 17 Jul 2006 Revisions received 11 Aug 2006 Accepted 13 Sep 2006 Published 13 Sep 2006 Critical Care 2006 10 R131 doi cc5043 This article is online at http content 10 5 R131 2006 Buise et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Complications of oesophagectomy and gastric tube reconstruction include leakage and stenosis which may be due to compromised microvascular blood flow MBF in gastric tissue. We recently demonstrated that decreased MBF could be improved perioperatively by topical administration of nitroglycerin. The aim of the present study was to investigate whether nitroglycerin administered intravenously during gastric tube reconstruction could preserve tissue blood flow and oxygenation in the gastric fundus and reduce the incidence of postoperative leakage. Methods In this single-centre prospective double-blinded study we randomized 32 patients scheduled for oesophagectomy into two groups. The intervention group received intravenous nitroglycerin during gastric tube reconstruction .