tailieunhanh - báo cáo khoa học: " Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening | Tong et al. BMC Plant Biology 2011 11 148 http 1471-2229 11 148 BMC Plant Biology METHODOLOGY ARTICLE Open Access Multiallelic epistatic model for an out-bred cross and mapping algorithm of interactive quantitative trait loci 1 1 3 3 1 Chunfa Tong Bo Zhang Zhong Wang Meng Xu Xiaoming Pang Jingna Si Minren Huang and Rongling Wu3 2 Abstract Background Genetic mapping has proven to be powerful for studying the genetic architecture of complex traits by characterizing a network of the underlying interacting quantitative trait loci QTLs . Current statistical models for genetic mapping were mostly founded on the biallelic epistasis of QTLs incapable of analyzing multiallelic QTLs and their interactions that are widespread in an outcrossing population. Results Here we have formulated a general framework to model and define the epistasis between multiallelic QTLs. Based on this framework we have derived a statistical algorithm for the estimation and test of multiallelic epistasis between different QTLs in a full-sib family of outcrossing species. We used this algorithm to genomewide scan for the distribution of mul-tiallelic epistasis for a rooting ability trait in an outbred cross derived from two heterozygous poplar trees. The results from simulation studies indicate that the positions and effects of multiallelic QTLs can well be estimated with a modest sample and heritability. Conclusions The model and algorithm developed provide a useful tool for better characterizing the genetic control of complex traits in a heterozygous family derived from outcrossing species such as forest trees and thus fill a gap that occurs in genetic mapping of this group of important but underrepresented species. Background Approaches for quantitative trait locus QTL mapping were developed originally for experimental crosses such as the backcross double haploid RILs or F2 derived from inbred lines 1-3 . Because of the homozygosity of inbred lines the Mendelian co .