tailieunhanh - Báo cáo hóa học: " New materials and devices for preventing catheter-related infections"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: New materials and devices for preventing catheter-related infections | Timsit et al. Annals of Intensive Care 2011 1 34 http content 1 1 34 Ù Annals of Intensive Care a SpringerOpen Journal REVIEW Open Access New materials and devices for preventing catheter-related infections 11 11 Jean-Frangois Timsit Yohann Dubois Clémence Minet Agnès Bonadona Maxime Lugosi Claire Ara-Somohano1 Rebecca Hamidfar-Roy1 and Carole Schwebel1 Abstract Catheters are the leading source of bloodstream infections for patients in the intensive care unit ICU . Comprehensive unit-based programs have proven to be effective in decreasing catheter-related bloodstream infections CR-BSIs . ICU rates of CR-BSI higher than 2 per 1 000 catheter-days are no longer acceptable. The locally adapted list of preventive measures should include skin antisepsis with an alcoholic preparation maximal barrier precautions a strict catheter maintenance policy and removal of unnecessary catheters. The development of new technologies capable of further decreasing the now low CR-BSI rate is a major challenge. Recently new materials that decrease the risk of skin-to-vein bacterial migration such as new antiseptic dressings were extensively tested. Antimicrobial-coated catheters can prevent CR-BSI but have a theoretical risk of selecting resistant bacteria. An antimicrobial or antiseptic lock may prevent bacterial migration from the hub to the bloodstream. This review discusses the available knowledge about these new technologies. Introduction Central venous catheters CVCs are inserted in approximately half of all patients in the intensive care unit ICU . In Europe the incidence density of catheter-related bloodstream infections CR-BSI ranges from 1 to per 1 000 patient-days 1 . CR-BSIs were associated with an attributable mortality of 0 to 2 and an additional stay length of 9-12 days 3 4 . In contrast to other nosocomial infections CR-BSI has many device-related risk factors. Consequently prevention should be possible provided that rigorous .