tailieunhanh - A Lange Medical Book Pediatrics on call - part 10

Ghi chú: liều duy trì 12 giờ sau khi tải liều. Dung sai phát triển an thần. Long nửa cuộc đời cho phép dùng thuốc hàng ngày duy nhất. Thực hiện theo mức cần thiết; phạm vi điều trị 15-40 mcg / mL. Phenylephrine (NEO-SYNEPHRINE) Chỉ định: thất bại mạch máu trong sốc quá mẫn, hoặc tụt huyết áp do thuốc gây ra, | 2. GENERIC DRUGS 709 Notes Give maintenance dose 12 hours after loading dose. Tolerance develops to sedation. Long half-life allows single daily dosing. Follow levels as needed therapeutic range 15-40 mcg mL. PHENYLEPHRINE NEO-SYNEPHRINE Indications Vascular failure in shock hypersensitivity or drug-induced hypotension nasal congestion mydriatic. Actions a-Adrenergic agonist. Dosage Mild to moderate hypotension 2-5 mg IM or SQ elevates BP for 2 hours mg IV elevates BP for 15 minutes. Severe hypotension or shock Children 5-20 mcg kg per dose IV q10-15min prn or mcg kg min continuous IV infusion Adults mg per dose q10-15min prn or continuous IV infusion at 100-180 mcg min once stabilized lower to maintenance rate of 40-60 mcg min. Nasal congestion Infants 6 months 1-2 drops of q3h Children 1-6years 2-3 drops of q4h prn Children 6-12 years 2-3 drops of q4h prn Children 12 years and adults 2-3 drops or 1-2 sprays of solution q4h into each nostril prn. Ophthalmologic Infants 1 year 1 drop of 15-30 minutes before exam Children and adults 1 drop of or 10 solution may repeat in 10-60 minutes as needed. Supplied Injection 10 mg mL nasal solution 1 ophthalmic solution 10 . Notes Promptly restore blood volume if loss has occurred. Use with extreme caution in patients with hyperthyroidism bradycardia partial heart block myocardial disease or severe arteriosclerosis. Use large veins for infusion to avoid extravasation phentolamine 10 mg in 10-15 mL of NS may be injected locally as antidote for extravasation. Activity of drug is potentiated by oxytocin MAO inhibitors and tricyclic antidepressants. PHENYTOIN DILANTIN Indications Seizure disorders. Actions Inhibits seizure spread in motor cortex. Dosage Neonates Load 15-20 mg kg IV in single or divided dose followed by maintenance dose of 5-8 mg kg day divided q8-12h. Infants children and adults Load 15-20 mg kg IV at max infusion rate of 25 mg .