tailieunhanh - A Lange Medical Book Pediatrics on call - part 9

Có ít hoạt động chống liên cầu khuẩn. Tương tác thuốc xảy ra với theophylline, caffeine, sucralfate, warfarin, didanosine, và thuốc kháng acid. Nên uống vào dạ dày trống rỗng. Điều chỉnh liều ở bệnh nhân suy thận. Ciprofloxacin, Nhãn khoa (CILOXAN) (XEM BẢNG VIII-6, P. 754) CIPROFLOXA CIN, OTIC (Cipro HC OTIC) Chỉ định: viêm tai giữa externa. Hành động: quinolone kháng sinh ức chế | 2. GENERIC DRUGS 627 Notes Has little activity against streptococci. Drug interactions occur with theophylline caffeine sucralfate warfarin didanosine and antacids. Should be taken on empty stomach. Adjust dose in patients with renal impairment. CIPROFLOXACIN OPHTHALMIC CILOXAN SEE TABLE VIII-6 P. 754 CIPROFLOXACIN OTIC CIPRO Hc OTIC Indications Otitis externa. Actions Quinolone antibiotic inhibits DNA gyrase. Dosage 3 drops in affected ear s twice daily for 7 days. Supplied Suspension ciprofloxacin and hydrocortisone 1 . Cisatracurium Nimbex Indications Adjunct to anesthesia to facilitate endotracheal intubation. Actions Nondepolarizing neuromuscular blocker. Dosage Initial mg kg IV followed by mg kg prn Continuous infusion 1-4 mcg kg min IV or 6-20 mcg kg min. Supplied Injection 2 mg mL 10 mg mL. Notes Patient must be intubated and on controlled ventilation. Intermediate onset not recommended for rapid sequence intubation. Undergoes rapid nonenzymatic degradation Hofmann elimination making dosage adjustment in patients with renal or hepatic impairment unnecessary. CISPLATIN PLATINOL-AQ Indications Treatment of Hodgkin and non-Hodgkin lymphoma head or neck cancer cervical testicular ovarian and breast cancer lung cancer brain tumors neuroblastoma osteosarcoma. Actions Antineoplastic alkylating agent. Dosage Refer to individual protocols. Verify doses 120 mg m2 per course to prevent overdose. Supplied Injection 1 mg mL. Notes Adjust dose in patients with renal impairment. Maintain adequate hydration and urine output to prevent nephrotoxicity. Toxicities include 628 VIII COMMONLY USED MEDICATIONS allergic reactions high-frequency hearing loss peripheral stocking-glove type neuropathy cardiotoxicity hypomagnesemia mild myelosuppression and hepatotoxicity. CITRATE AND CITRIC ACID BICITRA Indications Metabolic acidosis. Actions Alkalinizing agent. Dosage 2-3 mEq kg day PO divided 3-4 times daily or 5-15 mL after meals and at bedtime. Supplied Oral solution