tailieunhanh - báo cáo hóa học: " SUVref: reducing reconstruction-dependent variation in PET SUV"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: SUVref: reducing reconstruction-dependent variation in PET SUV | Kelly and Declerck EJNMMI Research 2011 1 16 http content 1 1 16 9 EJNMMI Research a SpringerOpen Journal ORIGINAL RESEARCH Open Access SUVref reducing reconstruction-dependent variation in PET SUV Matthew D Kelly and Jerome M Declerck Abstract Background We propose a new methodology reference Standardised Uptake Value SUVref for reducing the quantitative variation resulting from differences in reconstruction protocol. Such variation that is not directly addressed by the use of SUV or the recently proposed PERCIST can impede comparability between positron emission tomography PET CT scans. Methods SUVref applies a reconstruction-protocol-specific phantom-optimised filter to clinical PET scans for the purpose of improving comparability of quantification. The ability of this filter to reduce variability due to differences in reconstruction protocol was assessed using both phantom and clinical data. Results SUVref reduced the variability between recovery coefficients measured with the NEMA image quality phantom across a range of reconstruction protocols to below that measured for a single reconstruction protocol. In addition it enabled quantitative conformance to the recently proposed EANM guidelines. For the clinical data a significant reduction in bias and variance in the distribution of differences in SUV resulting from differences in reconstruction protocol greatly reduced the number of hot spots that would be misclassified as undergoing a clinically significant change in SUV. Conclusions SUVref significantly reduces reconstruction-dependent variation in SUV measurements enabling increased confidence in quantitative comparison of clinical images for monitoring treatment response or disease progression. This new methodology could be similarly applied to reduce variability from scanner hardware. Keywords PET SUV reconstruction FDG PERCIST Background The Standardised Uptake Value SUV is a widely used metric for quantifying radiotracer particularly 18