tailieunhanh - Báo cáo y học: "Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effects of recombinant human growth hormone on HIV-1-specific T-cell responses, thymic output and proviral DNA in patients on HAART: 48-week follow-up. | Journal of Immune Based Therapies and Vaccines BioMed Central Open Access Original research Effects of recombinant human growth hormone on HIV-1-specific T-cell responses thymic output and proviral DNA in patients on HAART 48-weeik follow-up Anna A Herasimtschuk 1 Samantha J Westrop1 Graeme J Moyle2 Jocelyn S Downey1 and Nesrina Imami 1 Address Department of Immunology Imperial College London Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK and 2Department of HIV GU Medicine Imperial College London Chelsea and Westminster Hospital 369 Fulham Road London SW10 9NH UK Email Anna A Herasimtschuk - Samantha J Westrop - Graeme J Moyle - gm@ Jocelyn S Downey - Nesrina Imami - Corresponding author Published 31 October 2008 Received 25 September 2008 Journal of Immune Based Therapies and Vaccines 2008 6 7 doi l 476-85 18-6-7 Accepted 31 October 2008 This article is available from http content 6 1 7 2008 Herasimtschuk et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Efficacious immune-based therapy in treated chronic HIV-1 infection requires the induction of virus-specific CD4 T cells and subsequent maturation and maintenance of specific memory CD8 T cells. Concomitant daily administration of recombinant human growth hormone rhGH with highly active antiretroviral therapy HAART was used in chronically infected patients with lipodystrophy in an attempt to reconstitute these virus-specific T-cell responses. Methods Individuals with chronic HIV-1 infection on HAART were enrolled on a randomized double-blinded placebo-controlled study to .

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