tailieunhanh - Báo cáo y học: "Susceptibility of the human retrovirus XMRV to antiretroviral inhibitor"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors. | Smith et al. Retrovirology 2010 7 70 http content 7 1 70 RETR0VIR0L0GY RESEARCH Open Access Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors Robert A Smith1 Geoffrey S Gottlieb2 A Dusty Miller1 3 Abstract Background XMRV xenotropic murine leukemia virus-related virus is the first known example of an exogenous gammaretrovirus that can infect humans. A limited number of reports suggest that XMRV is intrinsically resistant to many of the antiretroviral drugs used to treat HIV-1 infection but is sensitive to a small subset of these inhibitors. In the present study we used a novel marker transfer assay to directly compare the antiviral drug sensitivities of XMRV and HIV-1 under identical conditions in the same host cell type. Results We extend the findings of previous studies by showing that in addition to AZT and tenofovir XMRV and HIV-1 are equally sensitive to AZddA 3 -azido-2 3 -dideoxyadenosine AZddG 3 -azido-2 3 -dideoxyguanosine and adefovir. These results indicate that specific 3 -azido or acyclic nucleoside analog inhibitors of HIV-1 reverse transcriptase RT also block XMRV infection with comparable efficacy in vitro. Our data confirm that XMRV is highly resistant to the non-nucleoside RT inhibitors nevirapine and efavirenz and to inhibitors of HIV-1 protease. In addition we show that the integrase inhibitors raltegravir and elvitegravir are active against XMRV with EC50 values in the nanomolar range. Conclusions Our analysis demonstrates that XMRV exhibits a distinct pattern of nucleoside analog susceptibility that correlates with the structure of the pseudosugar moiety and that XMRV is sensitive to a broader range of antiretroviral drugs than has previously been reported. We suggest that the divergent drug sensitivity profiles of XMRV and HIV-1 are partially explained by specific amino acid differences in their respective protease RT and integrase sequences. Our data provide a basis for choosing specific .

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