tailieunhanh - Báo cáo y học: "CpG increases vaccine antigen-specific cell-mediated immunity when administered with hepatitis B vaccine in HIV infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: CpG increases vaccine antigen-specific cell-mediated immunity when administered with hepatitis B vaccine in HIV infection. | Journal of Immune Based Therapies and Vaccines BioMed Central Open Access CpG increases vaccine antigen-specific cell-mediated immunity when administered with hepatitis B vaccine in HIV infection Jonathan B Angel 11 2 Curtis L Cooper1 2 Jennifer Clinch1 Charlene D Young1 Andreane Chenier1 Karl G Parato1 Michael Lautru1 Heather Davis3 and Donald W Cameron1 2 Address 1Ottawa Health Research Institute 501 Smyth Rd. Ottawa ON K1H 8L6 Canada 2Division of Infectious Diseases University of Ottawa Ottawa Hospital - General Campus 501 Smyth Rd. Ottawa ON K1H 8L6 Canada and 3Coley Pharmaceuticals 340 Terry Fox Dr. Suite 200 Ottawa ON K2K 3A2 Canada Email Jonathan B Angel - jangel@ Curtis L Cooper - ccooper@ Jennifer Clinch - Jenniferclinch@ Charlene D Young - cyoung@ Andreane Chenier - Karl G Parato - Kparato@ Michael Lautru - mlautru@ Heather Davis - hdavis@ Donald W Cameron - bcameron@ Corresponding author fEqual contributors Published 12 August 2008 Received 13 May 2008 Journal of Immune Based Therapies and Vaccines 2008 6 4 doi 1476-8518-6-4 Accepted 12 August 2008 This article is available from http content 6 1 4 2008 Angel et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Lack of adequate adjuvancy is a possible explanation for lack of vaccine immunogenecity. Immunostimulatory CpGs are potent vaccine adjuvants and may be an important component of the development vaccines particularly those for which a cellular immune response is required for protection. We have previously demonstrated