tailieunhanh - Báo cáo y học: " HIV interactions with monocytes and dendritic cells: viral latency and reservoirs"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology Research cung cấp cho các bạn kiến thức về ngành y đề tài:" HIV interactions with monocytes and dendritic cells: viral latency and reservoirs. | Retrovirology BioMed Central Open Access HIV interactions with monocytes and dendritic cells viral latency and reservoirs Christopher M Coleman and Li Wu Address Department of Microbiology and Molecular Genetics Medical College ofWisconsin 8701 Watertown Plank Road Milwaukee WI 53226 USA Email Christopher M Coleman - ccoleman@ Li Wu - liwu@ Corresponding author Published I June 2009 Received 27 March 2009 Retrovirology 2009 6 51 doi 1742-4690-6-5 1 Accepted 1 June 2009 This article is available from http content 6 I 5I 2009 Coleman and Wu licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract HIV is a devastating human pathogen that causes serious immunological diseases in humans around the world. The virus is able to remain latent in an infected host for many years allowing for the long-term survival of the virus and inevitably prolonging the infection process. The location and mechanisms of HIV latency are under investigation and remain important topics in the study of viral pathogenesis. Given that HIV is a blood-borne pathogen a number of cell types have been proposed to be the sites of latency including resting memory CD4 T cells peripheral blood monocytes dendritic cells and macrophages in the lymph nodes and haematopoietic stem cells in the bone marrow. This review updates the latest advances in the study of HIV interactions with monocytes and dendritic cells and highlights the potential role of these cells as viral reservoirs and the effects of the HIV-host-cell interactions on viral pathogenesis. Background Human immunodeficiency virus HIV remains a devastating human pathogen responsible for a world-wide pandemic of acquired immunodeficiency syndrome AIDS . Despite .