tailieunhanh - Báo cáo y học: "Corticosteroids influence the mortality and morbidity of acute critical illnes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Corticosteroids influence the mortality and morbidity of acute critical illness. | Available online http content 10 4 R101 Research Corticosteroids influence the mortality and morbidity of acute critical illness Mohamed Y Rady1 Daniel J Johnson1 2 Bhavesh Patel1 Joel Larson1 and Richard Helmers1 Department of Critical Care Medicine Mayo Clinic College of Medicine Mayo Clinic Hospital Mayo Clinic Phoenix Arizona USA department of Surgery Mayo Clinic College of Medicine Mayo Clinic Hospital Mayo Clinic Phoenix Arizona USA Corresponding author Mohamed Y Rady editorial@ Received 18 Apr 2006 Accepted 26 Jun 2006 Published 17 Jul 2006 Critical Care 2006 10 R101 doi cc4971 This article is online at http content 10 4 R101 2006 Rady et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Use of corticosteroids for adrenal supplementation and attenuation of the inflammatory and immune response is widespread in acute critical illness. The study hypothesis was that exposure to corticosteroids influences the mortality and morbidity in acute critical illness. Methods This case-control retrospective study was performed in a single multidisciplinary intensive care unit at a tertiary care institution and consisted of 10 285 critically ill patients admitted between 1 January 1999 and 31 December 2004. Demographics comorbidities acute illness characteristics including severity measured by Sequential Organ Failure Assessment concurrent medications therapeutic interventions and incidence of infections were obtained from electronic medical records were examined with multiple regression analysis and were adjusted for propensity of corticosteroid exposure. The primary outcome was hospital death and the secondary outcome was transfer to a care facility at

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