tailieunhanh - Bóa cáo y học: "Prospective, randomized trial comparing fluids and dobutamine optimization of oxygen delivery in high-risk surgical patients [ISRCTN42445141]"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Prospective, randomized trial comparing fluids and dobutamine optimization of oxygen delivery in high-risk surgical patients [ISRCTN42445141]. | Available online http content 10 3 R72 Research Prospective randomized trial comparing fluids and dobutamine optimization of oxygen delivery in high-risk surgical patients iSrCTN42445141 Suzana M Lobo Francisco R Lobo Carlos A Polachini Daniela S Patini Adriana E Yamamoto Neymar E de Oliveira Patricia Serrano Helder S Sanches Marco A Spegiorin Marcio M Queiroz Antonio C Christiano Jr Elisangela F Savieiro Paula A Alvarez Silvia P Teixeira and Geni S Cunrath Open Access Division of Critical Care Medicine Departments of Internal Medicine Anesthesiology and Surgery Medical School - FUNFARME and Hospital de Base São José do Rio Preto São Paulo Brazil Corresponding author Suzana M Lobo suzanalobo@ Received 16 Mar 2006 Accepted 6 Apr 2006 Published 12 May 2006 Critical Care 2006 10 R72 doi cc4913 This article is online at http content 10 3 R72 2006 Lobo et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Preventing perioperative tissue oxygen debt contributes to a better postoperative recovery. Whether the beneficial effects of fluids and inotropes during optimization of the oxygen delivery index DO2I in high-risk patients submitted to major surgeries are due to fluids to inotropes or to the combination of the two is not known. We aimed to investigate the effect of DO2I optimization with fluids or with fluids and dobutamine on the 60-day hospital mortality and incidence of complications. Methods A randomized and controlled trial was performed in 50 high-risk patients elderly with coexistent pathologies undergoing major elective surgery. Therapy consisted of pulmonary artery catheter-guided hemodynamic optimization during the operation and 24 hours postoperatively .

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