tailieunhanh - Báo cáo y học: "Effect of a lung recruitment maneuver by high-frequency oscillatory ventilation in experimental acute lung injury on organ blood flow"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of a lung recruitment maneuver by high-frequency oscillatory ventilation in experimental acute lung injury on organ blood flow. | Available online http content 10 4 R100 Research Effect of a lung recruitment maneuver by high-frequency oscillatory ventilation in experimental acute lung injury on organ blood flow in pigs Matthias David1 Hendrik W Gervais1 Jens Karmrodt1 Arno L Depta1 Oliver Kempski2 and Klaus Markstaller1 Department of Anesthesiology Johannes Gutenberg-University Mainz Germany institute of Neurosurgical Pathophysiology Johannes Gutenberg-University Mainz Germany Corresponding author Matthias David david@ Received 28 Mar 2006 Revisions requested 21 Apr 2006 Revisions received 11 May 2006 Accepted 19 Jun 2006 Published 12 Jul 2006 Critical Care 2006 10 R100 doi cc4967 This article is online at http content 10 4 R1 00 2006 David et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The objective was to study the effects of a lung recruitment procedure by stepwise increases of mean airway pressure upon organ blood flow and hemodynamics during high-frequency oscillatory ventilation HFOV versus pressure-controlled ventilation PCV in experimental lung injury. Methods Lung damage was induced by repeated lung lavages in seven anesthetized pigs 23-26 kg . In randomized order HFOV and PCV were performed with a fixed sequence of mean airway pressure increases 20 25 and 30 mbar every 30 minutes . The transpulmonary pressure systemic hemodynamics intracranial pressure cerebral perfusion pressure organ blood flow fluorescent microspheres arterial and mixed venous blood gases and calculated pulmonary shunt were determined at each mean airway pressure setting. Results The transpulmonary pressure increased during lung recruitment HFOV from 15 3 mbar to 22 2 mbar P PCV from

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