tailieunhanh - Báo cáo khoa học: "Use of prophylactic fluconazole in a neonatal intensive care unit: efficacy is similar to that described in adult high-risk surgical patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Use of prophylactic fluconazole in a neonatal intensive care unit: efficacy is similar to that described in adult high-risk surgical patients. | Available online http content 10 1 402 Letter Use of prophylactic fluconazole in a neonatal intensive care unit efficacy is similar to that described in adult high-risk surgical patients Paolo Manzoni Daniele Farina MariaLisa Leonessa Claudio Priolo and Giovanna Gomirato Neonatology and Hospital NICU Azienda Ospedaliera Regina Margherita Turin Italy Corresponding author Paolo Manzoni paolomanzoni@ Published 5 January 2006 Critical Care 2006 10 402 doi cc3958 This article is online at http content 10 1 402 2006 BioMed Central Ltd See related research by Ho et al. in issue http content 9 6 R710 We read with great interest the recent article by Ho and coworkers 1 concerning the use of prophylactic fluconazole in high-risk surgical patients in which those authors reported on seven randomized controlled studies from the Cochrane Controlled Trial Register. Ho and colleagues concluded that the use of prophylactic fluconazole in immunocompetent high-risk surgical patients is associated with a reduced incidence of candidaemia fewer patients requiring systemic amphotericin B as rescue therapy for systemic fungal infection and no increase in the proportion of patients colonized with or infected with fluconazole-resistant fungi but with only a trend toward a reduction in hospital mortality. In addition to the high-risk surgical patients considered by Ho and coworkers 1 preterm neonates in the neonatal intensive care unit are at increased risk for fungal colonization and infection but - despite positive reports from a limited number of institutions including ours 2-4 - the use of prophylactic fluconazole in these subsets is not yet viewed as a standard of care 5 . Nevertheless in our tertiary neonatal intensive care unit we began to use fluconazole in 2001 in all neonates with birth weight less than 1500 g and our findings are fully consistent with the data reported by Ho and colleagues. In particular when we analyzed .