tailieunhanh - Báo cáo y học: "Macrophage migration inhibitory factor: controller of systemic inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Macrophage migration inhibitory factor: controller of systemic inflammation. | Available online http content 10 2 138 Commentary Macrophage migration inhibitory factor controller of systemic inflammation Douglas F Larson and Katherine Horak Sarver Heart Center and Departments of Surgery and Medical Pharmacology College of Medicine The University of Arizona Tucson Arizona USA Corresponding author Douglas F Larson dflarson@ Published 6 April 2006 This article is online at http content 10 2 138 2006 BioMed Central Ltd Critical Care 2006 10 138 doi cc4899 See related research by de Mendonga-Filho et al. in this issue http content 10 2 R46 Abstract Macrophage migration inhibitory factor MIF is a cytokine that is secreted by the anterior pituitary and immune cells in response to surgical stress injury and sepsis. This cytokine appears to be a critical regulator of the inflammatory pathways leading to systemic inflammatory response syndrome and subsequent multiple organ dysfunction syndrome. This report provides an integrated scheme describing the manner by which MIF controls the neurohormonal response and the adaptive immune system namely the T-helper Th 1 and Th2 lymphocytes which results in the release of pro-inflammatory cytokines and the anti-inflammatory cytokine interleukin-10. The development of systemic inflammatory response syndrome and subsequent development of multiple organ dysfunction syndrome appear to be related to MIF levels and the balance of Th1 and Th2 function. Introduction For the survival for all living creatures an appropriate and balanced immune response to invading micro-organisms is essential. However in the case of cardiovascular surgery resembling sepsis and injury an exaggerated inflammatory response described as systemic inflammatory response syndrome SIRS may result in multiple organ dysfunction syndrome MODS . The report by de Mendonga-Filho and coworkers 1 included in this issue of Critical Care demonstrates that a SIRS cytokine namely macrophage migration .