tailieunhanh - Báo cáo y học: "Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein: a prospective observational study. | Available online http content 10 2 R63 Research Early identification of intensive care unit-acquired infections with daily monitoring of C-reactive protein a prospective observational study Pedro Póvoa Luís Coelho Eduardo Almeida Antero Fernandes Rui Mealha Pedro Moreira and Henrique Sabino Unidade de Cuidados Intensivos Hospital Garcia de Orta Almada Portugal Corresponding author Pedro Póvoa povoap@ Received 27 Jan 2006 Revisions requested 13 Feb 2006 Revisions received 21 Feb 2006 Accepted 14 Mar 2006 Published 24 Apr 2006 Critical Care 2006 10 R63 doi cc4892 This article is online at http content 10 2 R63 2006 Póvoa et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Manifestations of sepsis are sensitive but are poorly specific of infection. Our aim was to assess the value of daily measurements of C-reactive protein CRP temperature and white cell count WCC in the early identification of intensive care unit ICU -acquired infections. Methods We undertook a prospective observational cohort study 14 month . All patients admitted for 72 hours n 181 were divided into an infected n 35 and a noninfected group n 28 . Infected patients had a documented ICU-acquired infection and were not receiving antibiotics for at least 5 days before diagnosis. Noninfected patients never received antibiotics and were discharged alive. The progression of CRP temperature and WCC from day -5 to day 0 day of infection diagnosis or of ICU discharge was analyzed. Patients were divided into four patterns of CRP course according to a cutoff value for infection diagnosis of mg dl pattern A day 0 CRP mg dl and in the previous days at least once below the cutoff pattern

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