tailieunhanh - Báo cáo y học: "Oxygenation effect of interventional lung assist in a lavage model of acute lung injury: a prospective experimental study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Ethics review: Oxygenation effect of interventional lung assist in a lavage model of acute lung injury: a prospective experimental study. | Available online http content 10 2 R56 Research Oxygenation effect of interventional lung assist in a lavage model of acute lung injury a prospective experimental study Gunther Zick Inez Frerichs Dirk Schadler Gunnar Schmitz Sven Pulletz Erol Cavus Felix Wachtler Jens Scholz and Norbert Weiler Open Access Department of Anesthesiology and Intensive Care Medicine University Hospital Schleswig-Holstein Campus Kiel Germany Corresponding author Gunther Zick zick@ Received 20 Jan 2006 Revisions requested 21 Feb 2006 Revisions received 27 Feb 2006 Accepted 13 Mar 2006 Published 7 Apr 2006 Critical Care 2006 10 R56 doi cc4889 This article is online at http content 10 2 R56 2006 Zick et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The aim of the study was to test the hypothesis that a pumpless arteriovenous extracorporeal membrane oxygenator interventional lung assist ILA does not significantly improve oxygenation in a lavage model of acute lung injury. Methods The study was designed as a prospective experimental study. The experiments were performed on seven pigs 48-60 kg body weight . The pigs were anesthetized and mechanically ventilated. Both femoral arteries and one femoral vein were cannulated and connected with ILA. Acute lung injury was induced by repeated bronchoalveolar lavage until the arterial partial pressure of O2 was lower than 100 Torr for at least 30 minutes during ventilation with 100 O2. Results ILA was applied with different blood flow rates through either one or both femoral arteries. Measurements were repeated at different degrees of pulmonary gas exchange impairment with the pulmonary venous admixture ranging from to