tailieunhanh - Báo cáo y học: "Skin microcirculation and vasopressin infusion: a laser Doppler study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Skin microcirculation and vasopressin infusion: a laser Doppler study. | Available online http content 10 2 135 Commentary Skin microcirculation and vasopressin infusion a laser Doppler study Francis Bernard1 Alain Vinet2 3 and Colin Verdant1 3 intensive Care Service Hôpital du Sacré-Coeur de Montreal Université de Montreal Montreal Quebec Canada 2Department of Physiology and Institute of Biomedical Engineering Université de Montreal Montreal Quebec Canada 3Hôpital du Sacré-Coeur de Montreal Research Center Montreal Quebec Canada Corresponding author Colin Verdant c-verdant@ Published 29 March 2006 This article is online at http content 10 2 135 2006 BioMed Central Ltd Critical Care 2006 10 135 doi cc4884 See related research by Luckner et al. in this issue http content 10 2 R40 Abstract Use of arginine vasopressin in the management of refractory vasodilatory shock has been associated with development of ischaemic skin lesions. Because of the increasing popularity of arginine vasopressin it is important to evaluate its effects on microcirculatory blood flow. Such studies are crucial if we are to appreciate the microcirculatory consequences of our various resuscitation strategies. However methodological issues must always be considered because they can significantly influence interpretation of the results. Some aspects of use of laser Doppler to evaluate the microcirculation are reviewed within the context of recent findings presented by Luckner and coworkers in this issue of Critical Care. Introduction Arginine vasopressin AVP is increasingly used in the management of refractory vasodilatory shock. Indeed it was recently incorporated into the recommendations grade IIB proposed by the American Heart Association for treatment of refractory septic shock 1 and the guidelines of the Surviving Sepsis Campaign grade E 2 . However although the global haemodynamic effects of AVP are relatively well described its effects on the microcirculation are still largely unknown. In this issue of